Conditional false discovery rate

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August undefined, 2024

Webgeneralizing the false discovery rate of Banjamini and Hochberg [1]. In this article, we bring newer insight to the k-FDR considering a mixture model involving independent p-values before motivating the developments of some new procedures that control it. We prove the WebJun 4, 2024 · Benjamini Y, Hochberg Y. On the adaptive control of the false discovery rate in multiple testing with independent statistics. J Educ Behav Stat. 2000; 25(1):60–83. Article Google Scholar Chen JJ, Robeson PK, Schell MJ. The false discovery rate: a key concept in large-scale genetic studies. Canc Control. 2010; 17(1):58–62.

False Discovery Rate - an overview ScienceDirect Topics

WebNov 20, 2024 · Use of the conditional false discovery rate (cFDR) approach, which leverages pleiotropy identified from existing GWAS outputs, has been successful in … Webwhere is the number of false discoveries and is the number of true discoveries. The false discovery rate ( FDR) is then simply: [1] where is the expected value of . The goal is to keep FDR below a given threshold q. … limerick gaa club draw

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WebIn recent years, Greenwood et al. used a conditional false discovery rate statistical approach, taking advantage of several large GWAS on SCZ and cognitive traits in more … WebJan 1, 2024 · Conditional False Discovery Rate Analysis Of Genome-Wide Association Studies Uncovers Genetic LOCI Shared Between Schizophrenia And Volumes Of … WebJan 1, 2024 · Here, we used an alternative approach to address the question of genetic overlap, by applying the conditional false discovery rate (cFDR) approach. This statistical framework increases power for discovery by leveraging overlapping signal across GWAS. Importantly, cFDR analysis allows for identifying overlapping loci regardless of their ... hotels near marol metro station

Conditional false discovery rate

A direct approach to estimating false discovery rates conditional …

WebApr 25, 2013 · For each nominal p-value, an estimate of the conditional False Discovery Rate (FDR) was obtained from the conditional empirical cdfs . Using this conditional FDR method, we constructed two … WebBoca SM, Leek JT. A direct approach to estimating false discovery rates conditional on covariates. PeerJ. 2024;2024(12):e6035. doi: 10.7717/peerj.6035

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WebOct 17, 2016 · Summary. Wee introduce a new Empirical Bayes approach forward large-scale hypothesis testing, including estimating false discovery rates (FDRs), and effective sizes. Th WebOct 15, 2024 · These three methods have been shown to provide online control of the "modified" false discovery rate (mFDR) under a condition known as conditional superuniformity. However, to our knowledge, LORD & SAFFRON have only been shown to control the traditional false discovery rate (FDR) under an independence condition on …

WebDec 10, 2024 · A direct approach to estimating false discovery rates conditional on covariates PeerJ. 2024 Dec 10;6:e6035. doi: 10.7717/peerj.6035. eCollection 2024. … WebThis repository contains R functions to compute the 'Conditional False Discovery Rate', a method to analyse genome-wide association studies (GWAS) for related diseases originally proposed by Andreasson et al (2013), in the case where the two GWAS have shared controls.These functions widen the scope of the existing technique and enable improved …

WebMay 28, 2024 · The false discovery rate (FDR) measures the proportion of false discoveries among a set of hypothesis tests called significant. This quantity is typically estimated based on p -values or test statistics. In some scenarios, there is additional information available that may be used to more accurately estimate the FDR.

WebJun 6, 2024 · The conditional false discovery rate (cFDR) circumvents the difficulties of estimating PDFs by approximating the optimal ratio using cumulative density functions (CDFs) (Andreassen et al., 2013c). In this case, the covariate is generally a set of p-values arising from an analogous procedure on the same variables for a second ‘conditional ... hotels near marlow buckinghamshireWebNov 17, 2024 · Conditional local false discovery rate; Covariate–assisted inference; Structured multiple testing; Time series anomaly detection; Supplementary material. The supplementary material contains the proofs of main theorems, other theoretical results and additional numerical results. hotels near marmot basinWebNov 20, 2024 · Use of the conditional false discovery rate (cFDR) approach, which leverages pleiotropy identified from existing GWAS outputs, has been successful in discovering novel associated variants in related phenotypes. Here, genome-wide association study outputs for both von Korff chronic pain grade and for MDD were used to identify … limerick gaa shortsWebJul 20, 2024 · We introduce a new class of methods for finite-sample false discovery rate (FDR) control in multiple testing problems with dependent test statistics where the dependence is fully or partially known. Our approach separately calibrates a data-dependent p-value rejection threshold for each hypothesis, relaxing or tightening the threshold as … limerick gaa facebookWebMarginal false discovery rates 303 and Y are conditionally independent given A, so from a fully conditional regression perspective, B is a false discovery. Lastly, from a pathwise conditional perspective, B may or may not be a false discovery, depending on whether A is already included in the model or not at the point at which B enters. The central … limerick gaa results footballWebJul 20, 2024 · Download a PDF of the paper titled Conditional calibration for false discovery rate control under dependence, by William Fithian and Lihua Lei Download PDF … hotels near marquand moWebOct 15, 2024 · These three methods have been shown to provide online control of the "modified" false discovery rate (mFDR) under a condition known as conditional … hotels near marlins baseball stadium